Citicoline as Add-On Treatment in Alzheimer’s Disease: Tips from the Citicholinage Study

نویسندگان

  • Pietro Gareri
  • Alberto Castagna
چکیده

Citicoline or CDP-choline (cytidine-5'-diphosphate choline), is one of the most frequently prescribed drugs for cognitive impairment in several countries worldwide [1-3]. It is composed of ribose, pyrophosphate, cytosine (a nitrogenous base) and choline. In clinical practice, a number of different studies have shown that citicoline is effective in cognitive impairment (CI) of diverse etiology, such as post-stroke CI, Parkinson’s disease, glaucoma, head trauma and even Alzheimer’s dementia (AD) [1-3].

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

مقایسه اثربخشی داروی سیتی‌کولین با دارونما در درمان بیماران مبتلا به سکته مغزی

Background and Objective: Evidence is indicative of the positive effect of citicoline administration in stroke patients; however, there are controversies over this issue. Regarding this, the present study was conducted to investigate the efficacy of citicoline in acute stroke patients. Materials and Methods: This randomized clinical trial was conducted on 160 patients with hemorrhagic and isch...

متن کامل

Neurotrauma and Injury, Pain, Regeneration and Repair

Citicoline (CDP-choline) has undergone 13 phase III clinical stroke trials, and is being evaluated for treatment of Alzheimer’s and Parkinson’s diseases. Phospholipid degradation and generation of reactive oxygen species (ROS) are major factors causing neuronal injury in CNS trauma and neurodegenerative diseases. Oxidative metabolism of arachidonic acid, which is released by the action of phosp...

متن کامل

The Effects of Citicoline on Cerebrovascular Hemodynamic Status in Ischemic Stroke Patients

Introduction: Some recent studies have shown that citicoline improves clinical symptoms in patients with stroke. Citicoline's mechanism of action in improving the clinical symptoms is not recognized yet. The aim of this study was to evaluate the cerebrovascular hemodynamic status in patients with ischemic stroke treated with citicoline compared with the control group. <st...

متن کامل

Ligand-based pharmacophore modeling to identify plant-derived acetylcholinesterase inhibitor natural compounds in Alzheimer’s disease

Background: Alzheimer’s disease (AD) is a neurodegenerative disease characterized by decreased cognitive function in patients due to forming Aβ peptides and neurofibrillary tangles (NFT) in the brain. Therefore, the need to develop new treatments can reduce this risk. Acetylcholinesterase is one of the targets used in the design of new drugs for the treatment of AD. The researchers obtain new i...

متن کامل

Tacrine-Flavonoid Quercetin Hybride as a MTDL Ligand against Alzheimer’s Disease with Metal Chelating and AChE, BChE, AChE-induced Aβ Aggregation Inhibition Properties: A Computational Study

AChE is an enzyme that is predominate in a healthy brain, while BChE is considered to play a minor role in regulating the levels of ACh (memory molecule) in the brain. In addition to setting the ACh level, these two enzymes also facilitate Aβ aggregation by forming stable complexes and participate in the abnormal phosphorylation of the tau protein, which also contribute to the development of Al...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2017